| Description | JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body. |
| Target activity | ADAM8:12 nM (IC50), MMP9:>500000 nM (IC50), MMP9:1630 nM (IC50), ADAM10:150 nM (IC50), MMP12:9.4 nM (IC50), MMP14:19500 nM (IC50), MMP8:240 nM (IC50), ADAM17:1.9 nM (IC50) |
| Synonyms | JG 26, JG-26 |
| molecular weight | 594.27 |
| Molecular formula | C19H22Br2N4O6S |
| CAS | 1464910-32-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (84.14 mM), Sonication is recommended. |
| References | 1. Doretta Cuffaro, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793. |