| Description | Jedi2 is a Piezo1 activator rather than a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a K d of 2770 μM [1]. |
| In vitro | Jedi2 evokes Piezo1-mediated Ca 2+ influx. Jedi2 (200 μM) elicits dose-dependent responses specifically in mPiezo1-transfected cells while not in mPiezo2- or vector-transfected cells [1]. Jedi2 (1 mM) causes an increase in Ca 2+ in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM) [1]. |
| molecular weight | 208.23 |
| Molecular formula | C10H8O3S |
| CAS | 651005-90-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |