PeptideDB

JBSNF-000088

CAS No.: 7150-23-4

JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders
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Description JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.
Target activity NNMT (monkey):2.8 µM (IC50), NNMT (human):1.8 µM (IC50), NNMT (mouse):5.0 µM (IC50)
Synonyms JBSNF000088
molecular weight 152.15
Molecular formula C7H8N2O2
CAS 7150-23-4
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility DMSO: 50 mg/mL (328.62 mM)
References 1. Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7. PubMed PMID: 29483571; PubMed Central PMCID: PMC5826917.