| Description | Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 value of 872 nM, demonstrating over 115-fold greater selectivity for AChE compared to butyrylcholinesterase (BuChE) [2]. Additionally, Jatrorrhizine hydroxide impedes the uptake of serotonin (5-HT) and norepinephrine (NE) by inhibiting uptake-2 transporters, further contributing to its pharmacological profile [3]. |
| molecular weight | 355.38 |
| Molecular formula | C20H21NO5 |
| CAS | 483-43-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |