| Description | Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 μM). Jarin-1 specific suppresses bioactive JA biosynthesis in Arabidopsis and other plants. |
| In vitro | MeJA与Jarin-1处理促进了FaANR及其相关转录因子如FabHLH33和FaMYB9/11的上调，同时也促进了FaJMT与FaJAR1.2的上调。在FaMYB1/9/10/11基因的启动子区域发现了JA响应元素。相较于仅MeJA处理的果实，Jarin-1和MeJA + Jarin-1处理的果实中原花青素(PA)含量更高。通过将Jarin-1应用于MeJA处理的果实可以上调PA生物合成相关基因，从而增加草莓中PA的积累。与Jarin-1处理相比，仅MeJA处理的草莓果皮更红，花青素含量更高，同时发现了FaANS和FaUFGT基因的上调[1]。 |
| molecular weight | 471.55 |
| Molecular formula | C28H29N3O4 |
| CAS | 1212704-51-2 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30.6 mg/mL (64.9 mM), Sonication is recommended. |
| References | 1. Delgado LD, et al. Application of a JA-Ile Biosynthesis Inhibitor to Methyl Jasmonate-Treated Strawberry Fruit Induces Upregulation of Specific MBW Complex-Related Genes and Accumulation of Proanthocyanidins. Molecules. 2018 Jun 13;23(6). pii: E1433. 2. Meesters C, et al. A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nat Chem Biol. 2014 Oct;10(10):830-6. |