| Description | JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. |
| Target activity | JAK2:70 nM, JAK1:5 nM, TYK2:34 nM, JAK3:3 nM |
| molecular weight | 340.38 |
| Molecular formula | C18H20N4O3 |
| CAS | 1400876-94-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311. |