| Description | ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations. |
| molecular weight | 331.86 |
| Molecular formula | C18H18ClNOS |
| CAS | 1802013-08-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Moreno-Ortega AJ, Martínez-Sanz FJ, Lajarín-Cuesta R, de Los Rios C, Cano-Abad MF. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. doi: 10.1016/j.neuropharm.2015.02.016. PubMed PMID: 25908402. 2. Martínez-Sanz FJ, Lajarín-Cuesta R, González-Lafuente L, Moreno-Ortega AJ, Punzón E, Cano-Abad MF, de los Ríos C. Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger. Eur J Med Chem. 2016 Feb 15;109:114-23. doi: 10.1016/j.ejmech.2015.12.043. PubMed PMID: 26774037. 3. Martínez-Sanz FJ, Lajarín-Cuesta R, Moreno-Ortega AJ, González-Lafuente L, Fernández-Morales JC, López-Arribas R, Cano-Abad MF, de los Ríos C. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. doi: 10.1021/acschemneuro.5b00161. PubMed PMID: 26192029. |