| Description | Itepekimab (REGN-3500) is a potent monoclonal antibody against IL-33.Itepekimab reduces airway inflammation and associated tissue damage in in vivo experiments and can be used to study asthma. |
| Synonyms | REGN-3500, SAR-440340 |
| molecular weight | N/A |
| CAS | 2226742-52-3 |
| Storage | store at low temperature | store at -20°C |
| References | 1. Wechsler ME, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668. 2. Rabe KF, et al. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021 Nov;9(11):1288-1298. 3. Scott JB, et al. Novel treatments for pediatric atopic dermatitis. Curr Opin Pediatr. 2021 Aug 1;33(4):392-401. 4. Kosloski MP, et al. Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first-in-human and first-in-patient trials. Clin Transl Sci. 2022 Feb;15(2):384-395. |