| Description | Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). |
| Target activity | Aβ40:18.4 μM, Aβ42:3.6μM |
| Synonyms | CHF5074, CSP-1103 |
| molecular weight | 325.16 |
| Molecular formula | C16H11Cl2FO2 |
| CAS | 749269-83-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (153.77 mM) |
| References | 1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24. |