| Description | ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia. |
| In vitro | In human bone marrow mesenchymal stem cells, ISX-1 (0-33 μM) inhibits the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and promotes TCF/LEF-mediated gene transcription. ISX-1 inhibits the accumulation of intracellular lipid droplets(IC50 = 1.9 μM) and stimulated ALP activity(EC50 = 1.2 μM) in a dose-dependent manner[1]. |
| Synonyms | ISX 1 |
| molecular weight | 302.35 |
| Molecular formula | C14H14N4O2S |
| CAS | 909207-35-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.02 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Rodgers K, Papinska A, Mordwinkin N. Regulatory aspects of small molecule drugs for heart regeneration. Adv Drug Deliv Rev. 2016 Jan 15;96:245-52. 2. Doniach T, Hodgkin J. A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans. Dev Biol. 1984 Nov;106(1):223-35. 3. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74. |