| Description | Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin. |
| In vivo | 五组Wistar大鼠（每组n=6）接受了不同的处理，分别为静脉注射（IV）剂量（2.78mg/kg）的sodium escinate（相当于0.5mg/kg的Escin IB和0.5mg/kg的Isoescin IB）、静脉注射（0.5mg/kg）和口服剂量（4mg/kg）的纯Escin IB或Isoescin IB。sodium escinate的给药，由于包含两种异构体，导致Escin IB和Isoescin IB的末端半衰期（t1/2）和平均滞留时间（MRT）值高于单独给药的对应化合物。Escin IB和Isoescin IB的吸收非常差，观察到两种化合物的口服生物利用度（F）值<2%。这两种化合物在体内发生异构化，其中Escin IB转化为Isoescin IB的过程比Isoescin IB转化为Escin IB更为容易。 |
| molecular weight | 1131.26 |
| Molecular formula | C55H86O24 |
| CAS | 219944-46-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (88.40 mM) |
| References | 1. Wu XJ, et al. Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats.J Ethnopharmacol. 2014 Feb 3;151(2):839-45. |