| Description | ISOBERGAPTEN is a plant growth regulating substance, it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum; it may form an important class of natural defensive agents against fungi. |
| In vitro | Isobergapten、(3R,8S)-Falcarindiol、bergapten、angelicin、sphondin、pimpinellin、isopimpinellin 和 6-isopentenyloxyisobergapten 被确认为 Heracleum maximum 根部抗结核活性的主要成分，主要用于治疗结核等传染性疾病。 |
| Cell experiments | A methanolic extract of Heracleum maximum roots was subjected to bioassay guided fractionation using the microplate resazurin assay (MRA) to assess inhibitory activity against Mycobacterium tuberculosis strain H37Ra. The antimycobacterial constituents were identified by NMR, MS and polarimetry. |
| molecular weight | 216.19 |
| Molecular formula | C12H8O4 |
| CAS | 482-48-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: < 2.16 mg/mL (10 mM, insoluble or slightly soluble) |
| References | 1. Neill T O , Johnson J A , Webster D , et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins[J]. Journal of ethnopharmacology, 2013, 147(1):232-237. |
| Citations | 1. Li S, Kelly C, Knob R, et al.Analysis of Coumarin-Based Phototoxins in Citrus-Derived Essential Oils Using Liquid Chromatography-Mass Spectrometry.Chromatographia.2023: 1-11. |