| Description | ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages. |
| Target activity | MIF:7 μM |
| Synonyms | MIF Antagonist, ISO 1 |
| molecular weight | 235.24 |
| Molecular formula | C12H13NO4 |
| CAS | 478336-92-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (191.29 mM) |
| References | 1. Xu L, et al. Drug Discov Today. 2013 Jun;18(11-12):592-600. 2. Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82. 3. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4. 4. Dagia NM, et al. Eur J Pharmacol. 2009 Apr 1;607(1-3):201-12. 5. Li S, Nie K, Zhang Q, et al. Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease[J]. Neuroscience. 2019. |
| Citations | 1. Li S, Nie K, Zhang Q, et al. Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease. Neuroscience. 2019, 416: 50-62 |