| Description | Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively). |
| Target activity | HIV-1 (MDR):0.15 nM (EC50), HIV-1 (M184V):3.1 nM (EC50), HIV-1 (WT):0.068 nM (EC50) |
| Synonyms | MK-8591 |
| molecular weight | 293.25 |
| Molecular formula | C12H12FN5O3 |
| CAS | 865363-93-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 3 mg/mL (10.23 mM), Sonication and heating to 60℃ are recommended. DMSO: 100 mg/mL (341.01 mM), Sonication is recommended. |
| References | 1. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43. |