| Description | Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a dissociation constant (K D) of 3.65 pM, exhibiting chondroprotective and anti-inflammatory properties. It has the capability to bind to albumin, which prolongs its plasma half-life [1] [2] [3]. |
| In vitro | Isecarosmab 专一性地与 ADAMTS-5 结合，而不与 ADAMTS-1、ADAMTS-4 或 ADAMTS-15 发生结合[1]。 |
| In vivo | Isecarosmab (0.1-10 mg/kg，皮下注射，每三天一次) 能显著缓解DMM手术后小鼠内侧软骨的退化情况[1]。 |
| Synonyms | M-6495 |
| molecular weight | N/A |
| CAS | 2254082-79-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |