| Description | Isbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity. |
| In vivo | 在给予豚鼠一个剂量(106 µmol/kg i.p.)，能够完全防护对抗乙酰胆碱气雾引发的呼吸困难时，Isbufylline 抑制了血小板激活因子(PAF)和抗原诱导的嗜酸性粒细胞浸润到支气管肺泡灌洗液中。 |
| molecular weight | 236.27 |
| Molecular formula | C11H16N4O2 |
| CAS | 90162-60-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (232.78 mM) |
| References | 1. Manzini S, et al. Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs. Eur J Pharmacol. 1993 Nov 16;249(3):251-7. 2. Meini S, et al. Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence. Pulm Pharmacol. 1993 Dec;6(4):279-86. 3. Celardo A, et al. Simultaneous determination of isbufylline and its major metabolites in rabbit blood and urine by reversed-phase high-performance liquid chromatography. J Chromatogr. 1991 Aug 23;568(2):407-18. |