| Description | Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV). isatin-β-thiosemicarbazone exhibits antiviral activity by inhibiting both HSV-1 and HSV-2. isatin-β-thiosemicarbazone is Isatin-β-thiosemicarbazone is an effective anti-poxvirus agent for the treatment of monkeypox, orthopox and cowpox viruses. |
| In vitro | Isatin-beta-thiosemicarbazone (IBT) 在14 muM 的浓度下能够抑制HeLa细胞中的痘苗病毒增殖。感染后最初3小时内，存在IBT的情况下病毒的脱氧核糖核酸（DNA）合成速率与对照培养物相同。[2] |
| Synonyms | IBT |
| molecular weight | 220.25 |
| Molecular formula | C9H8N4OS |
| CAS | 27830-79-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (510.8 mM), Sonication is recommended. |
| References | 1. Meis RJ, et al. Genetic and molecular biological characterization of a vaccinia virus gene which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT). Virology. 1991;182(2):442-454. 2. Katz E, et al. Synthesis of vaccinia virus polypeptides in the presence of isatin-beta-thiosemicarbazone. Antimicrob Agents Chemother. 1973;4(1):44-48. 3. Arndt WD, et al. Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. Virology. 2016;497:125-135. |