| Description | Irampanel is a neuroprotectant and anticonvulsant. |
| Synonyms | BIIR-561CL |
| molecular weight | 309.36 |
| Molecular formula | C18H19N3O2 |
| CAS | 206260-33-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Feigin V. Irampanel Boehringer Ingelheim. Curr Opin Investig Drugs. 2002 Jun;3(6):908-10. Review. PubMed PMID: 12137411. 2. Wienrich M, Brenner M, Löscher W, Palluk R, Pieper M, Potschka H, Weiser T. In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels. Br J Pharmacol. 2001 Jul;133(6):789-96. PubMed PMID: 11454651; PubMed Central PMCID: PMC1572840. 3. Weiser T, Wienrich M, Brenner M, Kubiak R, Weckesser G, Palluk R. The AMPA receptor/Na(+) channel blocker BIIR 561 CL is protective in a model of global cerebral ischaemia. Eur J Pharmacol. 2001 Jun 15;421(3):165-70. PubMed PMID: 11516432. 4. Weiser T, Iizuka M, Nishimura S, Akiba I, Barsoumian E, Zhou M, Steinhäuser C, Brenner M, Palluk R, Wienrich M. Characterization of the anticonvulsant and neuroprotectant BIIR 561 CL in vitro: effects on native and recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26. PubMed PMID: 11111837. |