| Description | IQB-782 is a mucolytic agent with mucolytic expectorant activity.IQB-782 inhibits thrombin-activating fibrinolytic inhibitor (TAFI), protects rats from tobacco smoke-induced respiratory obstruction, reduces the viscosity of gastric mucin suspensions in vitro, and may be useful in studies of obstructive lung disease.IQB-782 has been shown to reduce the viscosity of gastric mucin suspensions in vitro. |
| In vitro | IQB-782显示出 与TAFI相关的羧肽酶的抑制作用，对CPN和CPB的IC50分别为49μM和12μM[1]。 |
| Target activity | TAFI:(Kiapp)0.14 μM , TAFI:0.14 μM, Carboxypeptidase N:49 μM, Carboxypeptidase B:12 μM |
| molecular weight | 163.2 |
| Molecular formula | C4H9N3O2S |
| CAS | 40454-21-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71. 2. Moratalla R, et al. Pharmacological study of the new mucolytic drug N-guanyl-cysteine. Arzneimittelforschung. 1986 Jun;36(6):918-23. |