| Description | Ipamorelin (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats. |
| In vitro | In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).?A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor[1] |
| In vivo | In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml).?In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma.?Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma)[1]. |
| Synonyms | 伊帕瑞林, NNC-26-0161 |
| molecular weight | 711.85 |
| Molecular formula | C38H49N9O5 |
| CAS | 170851-70-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Raun K , Hansen B , Johansen N , et al. Ipamorelin, the first selective growth hormone secretagogue[J]. European Journal of Endocrinology, 1998, 139(5):552-561. 2. Johansen P B , Nowak J , Skj?Rb?K C , et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats[J]. Growth Hormone & Igf Research, 1999, 9(2):0-113. |