| Description | IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM. |
| In vivo | IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE)[1]. |
| Target activity | Nurr1:3.9 nM(EC50) |
| Synonyms | IP 7e, IP-7e, isoxazolo-pyridinone 7e |
| molecular weight | 390.43 |
| Molecular formula | C23H22N2O4 |
| CAS | 500164-74-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 95 mg/mL (243.32 mM), Sonication is recommended. |
| References | 1. Montarolo F, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9(9):e108791. 2. Hintermann S, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17(1):193-6. Epub 2006 Oct 10. |