| Description | Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. |
| Target activity | COX-2:26 nM (in CHO cells), COX-1 (human):18 nM Human |
| Synonyms | Indometacin-D4, 吲哚美辛-D4 |
| molecular weight | 361.81 |
| Molecular formula | C19H16ClNO4 |
| CAS | 87377-08-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. |