| Description | Indinavir sulfate (L735524 sulfate) is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. |
| In vitro | 在低浓度下(0.0003-10μmol/l)，indinavir充当正向异构调节剂(EC50=0.021μmol/l)；而当浓度超过10μmol/l，即在30-100μmol/l范围内，indinavir则作为α7-烟碱型乙酰胆碱受体的抑制剂。 |
| Target activity | HIV-1:0.41 nM |
| Synonyms | L735524 sulfate, MK-639 sulfate, 硫酸茚地那韦 |
| molecular weight | 711.87 |
| Molecular formula | C36H49N5O8S |
| CAS | 157810-81-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (140.48 mM) |
| References | 1. Ekins S , Mathews P , Saito E K , et al. α7-Nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease[J]. AIDS (London, England), 2017, 31(8). |