| Description | INCB-9471 HCl, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5, has potent inhibitory activity against monocyte migration and HIV-1 infection. |
| Synonyms | INCB 9471, INCB-9471, INCB9471, INCB-009471, INCB 009471, INCB009471 |
| molecular weight | 632.59 |
| Molecular formula | C30H42Cl2F3N5O2 |
| CAS | 869725-27-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Brown KC, Paul S, Kashuba AD. Drug interactions with new and investigational antiretrovirals. Clin Pharmacokinet. 2009;48(4):211-41. doi: 10.2165/00003088-200948040-00001. Review. PubMed PMID: 19492868; PubMed Central PMCID: PMC2857544. 2. Shin N, Solomon K, Zhou N, Wang KH, Garlapati V, Thomas B, Li Y, Covington M, Baribaud F, Erickson-Viitanen S, Czerniak P, Contel N, Liu P, Burn T, Hollis G, Yeleswaram S, Vaddi K, Xue CB, Metcalf B, Friedman S, Scherle P, Newton R. Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39. doi: 10.1124/jpet.111.179531. PubMed PMID: 21459966. |