| Description | INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site. |
| In vitro | 在人类视网膜微血管内皮细胞中，INCA-6（1.0, 2.5μM）显著降低VEGF及血清诱导的增殖，但不影响基线增殖[1]。在3-Hz细胞中，INCA-6（5μM）防止瞬时外向K+流的下调[2]。INCA-6（10μM）显著抑制大鼠初代微胶质细胞和BV-2细胞ATP诱导的CXCL2表达[3]。INCA-6（5μM）减少蛋白表达并降低与thapsigargin有无相关的SERCA2转录水平[4]。 |
| In vivo | INCA-6（2.5、5.0和25.0 μM；眼内注射）显著减少了氧气诱导的视网膜病变中的病理性新生血管，并以剂量依赖的方式降低了OIR的严重性[1]。 |
| Synonyms | Triptycene-1,4-quinone |
| molecular weight | 284.31 |
| Molecular formula | C20H12O2 |
| CAS | 3519-82-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 2.84 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Colin A Bretz, et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7020-7. 2. Ling Xiao, et al. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 2008 Sep 26;103(7):733-42. 3. Miho Shiratori,et al. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem. 2010 Aug;114(3):810-9. 4. Anand Mohan Prasad, et al. Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H173-80. |