| Description | Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion |
| Target activity | 5-HT:32 nM (IC50) |
| Synonyms | 盐酸丙咪嗪, Imipramine (hydrochloride), Tofranil, G 22355, Imipramine HCl, Melipramine |
| molecular weight | 316.87 |
| Molecular formula | C19H25ClN2 |
| CAS | 113-52-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (315.59 mM) H2O: 100 mg/mL (315.59 mM) |
| References | 1. Glassman A H . The Clinical Pharmacology of Imipramine[J]. Archives of General Psychiatry, 1973, 28(5):649. 2. Yasuda S , Yoshida M , Yamagata H , et al. Imipramine Ameliorates Pain-related Negative Emotion via Induction of Brain-derived Neurotrophic Factor[J]. Cellular and Molecular Neurobiology, 2014, 34(8):1199-1208. |
| Citations | 1. Ma B, Shi S, Ren S, et al.Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability.European Journal of Pharmacology.2023: 176240. |