| Description | Imidacloprid-urea is a secondary metabolite of imidacloprid. Imidacloprid is a potent and widely used neonicotinoid with inhibitory effects on pests of cereals, vegetables, tea and cotton. imidacloprid-urea can occupy or block the adsorption sites of imidacloprid on the soil, which may affect the fate, transport and bioavailability of imidacloprid in the environment. |
| In vitro | Imidacloprid（0、10和20μM；4-6天）能降低脂肪细胞（3T3-L1）、肝细胞（HepG2）和肌管细胞（C2C12）细胞培养模型中胰岛素刺激下的葡萄糖吸收。使用imidacloprid会抑制蛋白激酶B（AKT）和核糖体S6激酶（S6K）的磷酸化。[3] |
| In vivo | Imidacloprid（剂量分别为0, 5, 10, 20 mg/kg/day；口服；雌性大鼠）在大鼠的大脑、肝脏和肾脏展现出轻微的病理变化。[4] |
| molecular weight | 211.65 |
| Molecular formula | C9H10ClN3O |
| CAS | 120868-66-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 11.2 mg/mL (53.2 mM ), Sonication is recommended. DMSO: 112.5 mg/mL (531.5 mM ), Sonication is recommended. |
| References | 1. Liu W, et al. Competitive sorption between imidacloprid and imidacloprid-urea on soil clay minerals and humic acids. J Agric Food Chem. 2002 ; 50(23):6823-6827. 2. Seifrtova M, et al. Distributions of imidacloprid, imidacloprid-olefin and imidacloprid-urea in green plant tissues and roots of rapeseed (Brassica napus) from artificially contaminated potting soil. Pest Manag Sci. 2017 ; 73(5):1010-1016. 3. Kim J, et al. Imidacloprid, a neonicotinoid insecticide, induces insulin resistance. J Toxicol Sci. 2013 ; 38(5):655-660. 4. Bhardwaj S, et al. A 90 days oral toxicity of imidacloprid in female rats: morphological, biochemical and histopathological evaluations. Food Chem Toxicol. 2010 ; 48(5):1185-1190. |