| Description | IMAB027 (ASP1650) is a specific monoclonal antibody targeting CLDN6 (Claudin 6), a membrane protein of tight junctions aberrantly overexpressed in multiple human cancers, notably in ovarian cancers. This compound exhibits anti-tumor properties and induces apoptosis specifically in CLDN6-positive ovarian and testicular cancer cell lines [1]. |
| In vitro | IMAB027 与CLDN6 特异性结合，而与其他密切相关的家族成员如Claudins 3、4及9的结合作用不同[1]。在表达CLDN6+的卵巢癌及睾丸癌细胞系中，IMAB027能够引发目标细胞激发选择性的抗体依赖细胞介导细胞毒性(ADCC)和补体依赖细胞毒性(CDC)[1]。 |
| In vivo | IMAB027能够降低CLDN6+人源细胞移植小鼠模型中的肿瘤增殖速率，并提升小鼠的整体存活率[1]。 |
| Synonyms | ASP1650 |
| molecular weight | N/A |
| CAS | 1650599-68-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |