| Description | Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the development of reflux oesophagitis. |
| Target activity | H+, K+-ATPase:6.0 μM (IC50) |
| Synonyms | IY81149, 艾普拉唑, IY 81149, IY-81149 |
| molecular weight | 366.44 |
| Molecular formula | C19H18N4O2S |
| CAS | 172152-36-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (163.74 mM) Ethanol: 12.5 mg/mL (34.11 mM), Sonication is recommended. |
| References | 1. Zhou G, Shi S, Zhang W, Tan Z, Chen Y, Guo D, Zhou H, Hu H, Tan J. Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments. Biomed Chromatogr. 2010 Oct;24(10):1130-5. doi: 10.1002/bmc.1416. PubMed PMID: 20352613. 2. Scarpignato C, Pelosini I, Di Mario F. Acid suppression therapy: where do we go from here? Dig Dis. 2006;24(1-2):11-46. Review. PubMed PMID: 16699262. |