| Description | I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity. |
| Synonyms | 4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸 |
| molecular weight | 340.37 |
| Molecular formula | C22H16N2O2 |
| CAS | 5496-35-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/ml (146.9 mM) |
| References | 1. Kortagere S, et al. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication. J Chem Inf Model. 2014 Nov 24;54(11):3080-90. 2. Kortagere S, et al. Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012 Aug;86(16):8472-81. |