| Description | Hydroxystilbamidine bis(methanesulfonate) is a dye capable of binding to both DNA and RNA. It also is a potent inhibitor of cellular ribonucleases. |
| In vitro | It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes [1]. |
| In vivo | Hydroxystilbamidine bis(methanesulfonate) is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine bis(methanesulfonate) depresses the plaque response of the treated mice. Fewer PFC is observed in Hydroxystilbamidine bis(methanesulfonate)-treated mice, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine bis(methanesulfonate) treated mice and the control group is essentially at the background level [2]. |
| molecular weight | 472.53 |
| Molecular formula | C18H24N4O7S2 |
| CAS | 223769-64-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Lizardi PM. Isolation of giant silk fibroin polysomes and fibroin mRNP particles using a novel ribonuclease inhibitor, hydroxystilbamidine. J Cell Biol. 1980 Oct;87(1):292-6. 2. Folds JD, et al. Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug. Infect Immun. 1975 Mar;11(3):441-4. |
Hydroxystilbamidine bis(methanesulfonate)
CAS No.: 223769-64-0
Hydroxystilbamidine bis(methanesulfonate) is a dye capable of binding to both DNA and RNA. It also is a potent inhibitor
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