| Description | Hydroquinine, is an organic compound and as a cinchona alkaloid closely related to quinine. |
| In vivo | 与安慰剂相比，活性化合物治疗组在用药期间肌肉痉挛的平均次数显著下降（16.1次或58%），其差异具有高度统计学意义（Wilcoxon检验p=0.004）。每日剂量300 mg的hydroquinine hydrobromide对于预防健康女性志愿者频繁发生的普通肌肉痉挛效果显著，hydroquinine的效果持续时间超过了给药期。该化合物耐受性良好。 |
| Animal experiments | Twenty healthy adult volunteers experiencing at least 3 muscle cramps a week (6 men, 14 women aged 38-78 yrs) were enrolled into this study, and 19 of them completed it. Hydroquinine hydrobromide (300 mg/day) was administered to group 1 (10 women) and placebo to group 2 (4 women, 6 men). The frequency, severity, duration and location of muscle cramps as well as short-term adverse drug effects were recorded in daily diaries. |
| Synonyms | 氢化奎宁, dihydroquinine |
| molecular weight | 326.43 |
| Molecular formula | C20H26N2O2 |
| CAS | 522-66-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/mL (199.12 mM) |
| References | 1. Jansen P H P , Veenhuizen K C W , Verbeek A L M , et al. Efficacy of hydroquinine in preventing frequent ordinary muscle cramp outlasts actual administration[J]. 1994, 122(2):157-161. |