| Description | hydrocotarnine is an inhibitor of Cbl. |
| In vivo | 在体内，通过使用镇痛药hydrocotarnine抑制Cbl，可增加结肠中炎症小体介导的IL-18分泌，并保护小鼠免受葡聚糖硫酸钠引起的结肠炎。总的来说，我们的新发现为SFK-Cbl轴在抑制NLRP3炎症小体激活方面的作用提供了新的见解，并确定了hydrocotarnine在疾病治疗中的新临床应用价值[2]。 |
| molecular weight | 221.25 |
| Molecular formula | C12H15NO3 |
| CAS | 550-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/ml (248.59 mM) |
| References | 1. Lin H C , Chen Y J , Wei Y H , et al. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition[J]. International Journal of Molecular Sciences, 21(14). 2. Chung I C , Yuan S N , Ouyang C N , et al. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation[J]. Cell Death & Disease, 2018, 9(11). |