| Description | hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment. |
| In vitro | hSMG-1 inhibitor 11e 对mTOR（IC50 = 45 nM）、PI3Kα/γ（IC50 = 61 nM）、PI3Kγ（IC50 = 92 nM）、CDK1（IC50 = 32 μM）和CDK2（IC50 = 7.1 μM）表现出900倍的选择性[1]。 |
| Target activity | mTOR:45 nM (IC50), PI3Kγ:92 nM (IC50), CDK1:32 μM (IC50), SMG-1 (human):<0.05 nM (IC50), PI3Kα:61 nM (IC50), CDK2:7.1 μM (IC50) |
| molecular weight | 517.6 |
| Molecular formula | C26H27N7O3S |
| CAS | 1402452-10-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (86.9 mM), Sonication is recommended. |
| References | 1. Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41. |