| Description | HPV16 E7 (86-93) acetate is a derived peptide of human leukocyte antigen A2.1 restricted HPV16 E7 with immunogenic property in cervical carcinomas. |
| In vitro | HPV16 E7肽负荷的自体树突状细胞能激发针对特定的细胞毒性CD8+ T细胞反应[1]。在体外与同源肽脉冲的树突状细胞刺激下，针对HPV16 E7 (86-93) acetate的特异性T细胞会扩增。这些特异性T细胞对肽脉冲靶细胞具有反应性。针对HPV16 E7 (86-93) acetate的特异性E711-20 T细胞对表达HPV16 E7的CaSki细胞系具有反应性。针对HPV16 E7 (86-93) acetate的前体T细胞在体外分化成针对HPV特异的效应细胞[2]。 |
| In vivo | HPV16 E7 (86-93)acetate在IVS培养中具有特异性T细胞扩增能力，但不识别自然表达HPV16 E7的细胞系CaSki。在转基因小鼠中观察到HPV16 E7 (86-93) acetate具有相似的现象。当HPV16 E7 (86-93) acetate加载到抗原呈递HLA I类分子上时，可以诱导细胞毒性T淋巴细胞反应[2]。 |
| Synonyms | HPV16 E7 (86-93) acetate(160212-93-1 Free base) |
| molecular weight | 875.08 |
| Molecular formula | C39H70N8O12S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Hoffmann TK, et al. T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx. Int J Cancer. 2006 Apr 15;118(8):1984-91. 2. Cheng WF, et al. Induction of human papillomavirus type 16-specific immunologic responses in a normal and an human papillomavirus-infected populations. Immunology. 2005 May;115(1):136-49. |