| Description | HPPE is a selective inhibitor of Bach1 that acts non-electrophilically. HPPE targets the heme-binding sites on the Bach1 protein and leads to the alleviation of Bach1-mediated repression. |
| molecular weight | 479.48 |
| Molecular formula | C21H20F3N5O3S |
| CAS | 1325721-55-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 3.6 mg/mL (7.5 mM) DMSO: 55 mg/mL (114.71 mM) |
| References | 1. Attucks, et al. Methods of inhibiting osteoclastogenesis and osteoclast activity using fused imidazole derivatives. WO2020117886 A1 2. Ahuja M, et al. Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118. |