| Description | HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1]. |
| In vitro | HPK1-IN-35（化合物31）（0.1、0.3、1、3 µM；1小时）能够剂量依赖性地抑制经抗CD3抗体（1 µg/mL）激活后的p-SLP76表达[1]。此外，HPK1-IN-35（0-10 µM；24小时）同样以剂量依赖性方式增强了Jurkat细胞IL-2的释放，其EC50值为1.19 μM [1]。 |
| Target activity | HPK1:3.5 nM |
| molecular weight | 584.69 |
| Molecular formula | C30H32N8O3S |
| CAS | 2935903-77-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |