| Description | Homo-VK-II-36 (Homo-V-II-36) is a carvedilol analogue that acts by inhibiting store- overload-induced calcium release through the RyR2 channel. |
| Synonyms | Homo-V-II-36 |
| molecular weight | 460.52 |
| Molecular formula | C27H28N2O5 |
| CAS | 1479049-35-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4.61 mg/mL (10 mM) |
| References | 1. Zhang JZ, McLay JC, Jones PP. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5. PubMed PMID: 24805197. 2. Zhou Q, Xiao J, Jiang D, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406. PubMed PMID: 21743453; PubMed Central PMCID: PMC3268079. |