| Description | Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei. |
| In vitro | Hoechst 34580 是一种适用于治疗阿尔茨海默病的候选化合物，其通过抑制Aβ生成发挥作用。在37 °C条件下，将50 μM Aβ42溶液与不同浓度的Hoechst 34580（分别为100、25、12.5、3.125、0.78、0.1及0.01 μM）共孵育70小时，研究结果显示Hoechst 34580能够以剂量依赖性方式抑制Aβ42的聚集。通过维持Aβ42浓度不变，测量Hoechst 34580的浓度，得到其IC50值为0.86±0.05 μM。 |
| Synonyms | HOE 34580 |
| molecular weight | 451.57 |
| Molecular formula | C27H29N7 |
| CAS | 23555-00-2 |
| Storage | keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 47 mg/mL (104.08 mM) |
| References | 1. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50. |