| Description | HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively). |
| In vitro | HMR 1556 suppresses Ito, ICa, L, and IKr (IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively)[1]. |
| Target activity | IKs (canine left ventricular myocytes):10.5 nM, IKs (guinea pig left ventricular myocytes):34 nM |
| molecular weight | 411.44 |
| Molecular formula | C17H24F3NO5S |
| CAS | 223749-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. 2. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7. |