| Description | HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway. This compound demonstrates promising anti-inflammatory and anti-sepsis properties, particularly in the context of renal injury [1]. |
| In vitro | HMGB1-IN-1（化合物6）（0-30 μM，0-48 h）在RAW264.7细胞和HK-2细胞中减少IL-1β和TNF-α的表达，并且剂量依赖性地抑制NLRP3、P-NF-κB p65和HMGB1在激活的HK-2细胞中的水平[1]。 |
| In vivo | "HMGB1-IN-1（化合物6）（15-30 mg/kg，腹腔注射）展现出显著的抗炎效应[1]。" |
| molecular weight | 1042.22 |
| Molecular formula | C57H75N3O15 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |