| Description | HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a drug-resistant variant (HIV-1 MDR), indicating strong antiviral activity against both strains [1]. |
| Target activity | HIV-1:0.32 nM, HIV-1 (NL4-3):0.29 μM (EC50), HIV-1 (MDR):1.90 μM (EC50) |
| molecular weight | 489.63 |
| Molecular formula | C25H35N3O5S |
| CAS | 2925287-55-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |