| Description | HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1]. |
| In vitro | HIV-1 integrase inhibitor 8 针对3′-处理(TC)和链转移(ST)活动，在含有Mn2+作为阳离子辅因子的条件下通过凝胶测定法进行了测试，其半抑制浓度(IC50)分别为275μM和231μM。重新使用Mg2+对HIV-1 integrase inhibitor 8 进行测试，针对链转移(ST)活动的IC50为200μM。HIV-1 integrase inhibitor 8 还抑制MCV拓扑异构酶和DNA再连接活动，IC50分别为500μM和200μM。HIV-1 integrase inhibitor 8 在HeLa细胞中引起细胞毒性，致死剂量50(LD50)为20μM[1]。 |
| molecular weight | 308.41 |
| Molecular formula | C21H24O2 |
| CAS | 1568-80-5 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (145.91 mM), Sonication is recommended. |
| References | 1. Molteni V, et al. A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family. J Med Chem. 2000 May 18;43(10):2031-9. |