| Description | HIV-1 inhibitor-54 is a potent HIV-1 inhibitor showing anti-HIV activity (EC50 : 32 nM) against WT HIV-1 (strain IIIB) x in MT-4 cells.HIV-1 inhibitor-54 can be used to study viral infections. |
| Target activity | L100I:3.3 μM(EC50), Y181C:0.84 μM(EC50), K103 N:0.52 μM(EC50), HIV-1 (wild-type):12 μM, HIV-1 (F227L+V106A):2.7 μM(EC50), Y188L:0.67 μM(EC50), HIV-1 (WT):0.032 μM(EC50), E138K:0.080 μM(EC50) |
| molecular weight | 534.63 |
| Molecular formula | C27H30N6O4S |
| CAS | 2771211-71-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023;248:115114. |