| Description | HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3]. |
| In vitro | APOBEC3G (A3G) is a host cytidine deaminase that can block HIV-1 replication and shows antiviral activity. However, HIV-1 develops the ability to hijack the cellular ubiquitin/proteasome degradation pathway [1]. HIV-1 inhibitor-47 targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), and works on the HIV-1 Vif-APOBEC3G interaction [2]. |
| molecular weight | 242.28 |
| Molecular formula | C12H14N6 |
| CAS | 137448-39-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |