| Description | HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) specifically inhibits the entry of multiple HIV-1 isolates. |
| Synonyms | HIV-1 Inhibitor-18A |
| molecular weight | 313.33 |
| Molecular formula | C14H11N5O2S |
| CAS | 331261-50-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (159.57 mM) |
| References | 1. Berinyuy E, Soliman MES. Identification of Novel Potential gp120 of HIV-1 Antagonist Using Per-Residue Energy Contribution-Based Pharmacophore modelling. Interdiscip Sci. 2017 Sep;9(3):406-418. doi: 10.1007/s12539-016-0174-7. Epub 2016 May 10. PubMed PMID: 27165479. 2. Berinyuy E, Soliman ME. A broad spectrum anti-HIV inhibitor significantly disturbs V1/V2 domain rearrangements of HIV-1 gp120 and inhibits virus entry. J Recept Signal Transduct Res. 2016;36(2):119-29. doi: 10.3109/10799893.2015.1056307. Epub 2015 Oct 8. PubMed PMID: 26446906. 3. Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat Chem Biol. 2014 Oct;10(10):845-52. doi: 10.1038/nchembio.1623. Epub 2014 Aug 31. PubMed PMID: 25174000; PubMed Central PMCID: PMC4231716. 4. Martin SF, Dorsey GO, Gane T, Hillier MC, Kessler H, Baur M, Mathä B, Erickson JW, Bhat TN, Munshi S, Gulnik SV, Topol IA. Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors. J Med Chem. 1998 May 7;41(10):1581-97. PubMed PMID: 9572884. |