| Description | Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. |
| In vitro | Hexaconazole is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L[1].It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively)[2]. |
| Cell experiments | The medium was poured into a set of two petriplates under aseptic conditions in a laminar flow hood.?When the medium in the plates was solidified, a mycelial disc of 0.5 cm diameter of freshly grown test fungi taken from periphery was inoculated upside down at the center of the plates.?These treated petri dishes were incubated at 28℃ until fungal growth in the control plates was almost complete.?Hexaconazole used as commercial fungicide and acetone served as control.?All the compounds were tested in triplicates.?The mycelia growth of fungi (mm) in both treated (T) and control (C) petri plates was measured diametrically in three different directions and growth inhibition (I) and corrected inhibition (IC) were calculated by using Abbott s formula[2] |
| Synonyms | 己唑醇, (-)-Hexaconazol |
| molecular weight | 314.21 |
| Molecular formula | C14H17Cl2N3O |
| CAS | 79983-71-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (175.04 mM) |
| References | 1. Tsuda M , Itoh H , Kato S . Evaluation of the systemic activity of simeconazole in comparison with that of other DMI fungicides[J]. Pest Management Science, 2004, 60(9):875-880. 2. Shakil N A , Kumar J , Pankaj, , et al. Synthesis and pesticidal activity of new N-alkyl-N-[1-(2-hydroxyphenyl) ethyl]amines[J]. Journal of Environmental Science and Health, Part B, 2009, 44(4):344-349. |