| Description | Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. |
| In vivo | 该小型稳定的furin抑制剂hexa-D-arginine酰胺有效阻断了PEA诱导的细胞溶解，并且本身不具有细胞毒性。向PEA处理的小鼠投给hexa-D-arginine显著提高了它们的存活率，同时也减少了循环中肿瘤坏死因子α的水平[1]。 |
| Target activity | Furin:106 nM (KI), PC1:13.2 mM (ki), PACE4:580 nM (KI) |
| molecular weight | 954.14 |
| Molecular formula | C36H75N25O6 |
| CAS | 673202-67-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 50mg/L (52.40 mM) DMSO: 20.96 mM |
| References | 1. Sarac M S , Cameron A , Lindberg I . The Furin Inhibitor Hexa-D-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo[J]. Infection and Immunity, 2002, 70(12):7136-7139. 2. Sarac M S , Peinado J R , Leppla S H , et al. Protection against Anthrax Toxemia by Hexa-D-Arginine In Vitro and In Vivo[J]. Infection and Immunity, 2004, 72(1):602-605. |