| Description | Herniarin (Ayapanin) is a natural coumarin with antitumor effect. |
| In vitro | Herniarin对乳腺癌细胞株MCF-7具有细胞毒性（IC50: 207.6 μM）。以100 μM浓度作用于MCF-7细胞时，亦能诱导其发生凋亡[1]。单独使用Herniarin对移行细胞癌（TCC）细胞并无显著的细胞毒性作用，但与5μg/mL的顺铂联合使用时，80 μg/mL的Herniarin明显增强了顺铂的抗肿瘤效果，并促进了染色质凝缩[2]。 |
| Synonyms | Methyl umbelliferyl ether, Ayapanin, 7-甲氧基香豆素, 7-Methoxycoumarin, Herniarine |
| molecular weight | 176.17 |
| Molecular formula | C10H8O3 |
| CAS | 531-59-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (283.82 mM) |
| References | 1. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30. 2. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62. |