| Description | hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects. |
| In vitro | hDHODH-IN-7是3-氯-6-环丙基吡啶的相应吡啶并咪唑同系物。hDHODH-IN-7 与含5-环吡啶的类似物在抗病毒作用模式上几乎无异，反映了含5-乙基嘧啶基团同系物的抗病毒效果。hDHODH-IN-7对于这类类似物是一个有效的抗病毒剂[1]。 |
| Target activity | DHODH:pMIC50:7.4 |
| Synonyms | DHODH-IN-9 |
| molecular weight | 366.43 |
| Molecular formula | C21H23FN4O |
| CAS | 1644156-41-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (136.45 mM) |
| References | 1. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98. |